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COX-2 Inhibitors Modulate IL-12 Signaling Through JAK-STAT Pathway Leading to Th1 Response in Experimental Allergic Encephalomyelitis

โœ Scribed by Gladson Muthian; Himanshu P. Raikwar; Caroline Johnson; Johnson Rajasingh; Amit Kalgutkar; Lawrence J. Marnett; John J. Bright


Book ID
106405624
Publisher
Springer
Year
2006
Tongue
English
Weight
730 KB
Volume
26
Category
Article
ISSN
0271-9142

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## Abstract Experimental allergic encephalomyelitis (EAE) is a Th1 cellโ€mediated autoimmune disease model of multiple sclerosis (MS). Vitamin D deficiency is commonly observed in MS patients and vitamin D supplements reduce the clinical symptoms of EAE and MS. Earlier studies have shown that in viv