Synthesis of [11C]celecoxib: a potential
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Jaya Prabhakaran; Vattoly J. Majo; Norman R. Simpson; Ronald L. Van Heertum; J.
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Article
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2005
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John Wiley and Sons
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French
⚖ 121 KB
11 C]Labeling of celecoxib, a COX-2 selective inhibitor and prescription drug for arthritis and pain has been achieved. The precursor molecule for the radiolabeling was synthesized from 4-bromoacetophenone in 4 steps with 23% overall yield. Stille reaction of N-[bis-(4-methoxyphenyl)phenylmethyl]-4-