The epidemiologic evidence and rodent studies suggest strongly that nonselective inhibitors of cyclooxygenase (COX) enzymes such as aspirin, inhibiting both COX-1 and COX-2 isoforms, reduce the incidence of and mortality from intestinal tumors. Genetically manipulated animals show that both Cox-1 an
✦ LIBER ✦
COX-2 Blockade in Cancer Prevention and Therapy,
✍ Scribed by Joanne van Ryn; Jacques van Meel
- Book ID
- 105752482
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 2003
- Tongue
- English
- Weight
- 34 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1420-908X
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## Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COX‐2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and bre
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