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Cover Picture: Synthesis of Somatostatin Mimetics Based on 1-Deoxynojirimycin (ChemMedChem 7/2008)

✍ Scribed by Vincent Chagnault; Jérôme Lalot; Paul V. Murphy

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 657 KB
Volume: 3
Category: Article
ISSN: 1860-7179
DOI: 10.1002/cmdc.200890026

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## Abstract The synthesis of novel somatostatin mimetics from 1‐deoxynojirimycin (DNJ) is described. The dipeptide mimetic, which respectively displayed the side chains of tryptophan and lysine at the nitrogen and O6 atoms of the iminosugar scaffold is a ligand (__K~i~__=3.2 μM) for the human somat

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