Cover Picture: Surface Change of Ras Enabling Effector Binding Monitored in Real Time at Atomic Resolution (ChemBioChem 7/2007)

Surface Change of Ras Enabling Effector

Surface Change of Ras Enabling Effector Binding Monitored in Real Time at Atomic Resolution

✍ Carsten Kötting; Angela Kallenbach; Yan Suveyzdis; Carolin Eichholz; Klaus Gerwe 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 566 KB

## Abstract Ras, the prototype of the Ras superfamily, acts as a molecular switch for cell growth. External growth signals induce a GDP‐to‐GTP exchange. This modifies the Ras surface (Ras~on~GTP) and enables effector binding, which then activates signal‐transduction pathways. GTP hydrolysis, cataly