Cover Picture: Supramolecular Catalysis of a Unimolecular Transformation: Aza-Cope Rearrangement within a Self-Assembled Host (Angew. Chem. Int. Ed. 48/2004)

✍ Scribed by Dorothea Fiedler; Robert G. Bergman; Kenneth N. Raymond

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 58 KB
• Volume: 43
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200490169

✦ Synopsis

A supramolecular metal–ligand assembly…︁ catalyzes the [3,3]‐sigmatropic rearrangement of enammonium guests in aqueous solution. The cover picture shows the proposed catalytic cycle. The space‐restrictive host cavity forces the substrates to bind in a reactive chairlike conformation and thus accelerates the rate of rearrangement. Release and hydrolysis of the rearranged product enable catalytic turnover. For more information, see the Communication by R. G. Bergman, K. N. Raymond, and D. Fiedler on p. 6748 ff.