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Cover Picture: Peptoid–Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1 (ChemBioChem 9/2012)

✍ Scribed by Dr. Fa Liu; Dr. Jung-Eun Park; Dr. Wen-Jian Qian; Dr. Dan Lim; Andrej Scharow; Prof. Thorsten Berg; Prof. Michael B. Yaffe; Dr. Kyung S. Lee; Dr. Terrence R. Burke Jr.

Book ID: 112016221
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 643 KB
Volume: 13
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.201290033

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Cover Picture: A Pan-Specific Inhibitor

Cover Picture: A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis (ChemBioChem 7/2009)

✍ Wolfgang Reindl; Juping Yuan; Andrea Krämer; Klaus Strebhardt ; Thorsten Berg 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 664 KB

## Abstract **The cover picture shows** the small molecule Poloxipan, a pan‐specific inhibitor of polo‐like kinases (Plks), and its effects on human cancer cells. Most inhibitors of protein kinases such as Plk1, which is a key player in mitosis, inhibit the enzyme ATP‐binding pocket. Due to the con