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Cover Picture: Pentanuclear Platinum(II) Macrocycles with Nucleobases (Angew. Chem. Int. Ed. 10/2004)

✍ Scribed by Michael J. Rauterkus; Bernt Krebs

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 22 KB
Volume: 43
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200490026

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✦ Synopsis

Metallocalixarenes such as the pentanuclear platinum(II) macrocycle shown in the cover picture, are prepared from a cisplatin analogue with tertiary amine ligands and the nucleobase uracil or thymine. The platinum(II) complex used in the synthesis of the macrocycle has a significant cytostatic activity as a result of its ability to bind to DNA. The background shows a crystal of calf thymus DNA. More details can be found in the Communication by M. J. Rauterkus and B. Krebs on page 1300 ff.

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