Cover Picture: Molecular Assembly of Multifunctional 99mTc Radiopharmaceuticals Using “Clickable” Amino Acid Derivatives (ChemMedChem 12/2010)

✍ Scribed by Prof. Thomas L. Mindt; Dr. Harriet Struthers; Priv.-Doz. Dr. Bernhard Spingler; Dr. Luc Brans; Prof. Dirk Tourwé; Dr. Elisa García-Garayoa; Prof. Roger Schibli

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 617 KB
• Volume: 5
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.201090054

✦ Synopsis

The cover picture shows the molecular assembly of multifunctional radiopharmaceuticals by click chemistry. Reaction of readily available building blocks yields conjugates that comprise a 99m Tc-based imaging probe for single photon emission computed tomography (SPECT) and two chemical/biological entities. The described approach is modular and allows the efficient preparation of a number of structurally diverse conjugates with high potential for medical applications. For more details, see the Full Paper by Thomas L. Mindt, Roger Schibli et al. on p. 2026 ff.