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Cover Picture: Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity (ChemBioChem 10/2011)

✍ Scribed by Samra Obeid; Dr. Andreas Schnur; Dr. Christian Gloeckner; Nina Blatter; Prof. Dr. Wolfram Welte; Prof. Dr. Kay Diederichs; Prof. Dr. Andreas Marx

Book ID: 102792789
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 908 KB
Volume: 12
Category: Article
ISSN: 1439-4227
DOI: 10.1002/cbic.201190043

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Learning from Directed Evolution: Thermu

Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity

✍ Samra Obeid; Dr. Andreas Schnur; Dr. Christian Gloeckner; Nina Blatter; Prof. Dr 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 727 KB

## Abstract DNA is being constantly damaged by endo‐ and exogenous agents such as reactive oxygen species, chemicals, radioactivity, and ultraviolet radiation. Additionally, DNA is inherently labile, and this can result in, for example, the spontaneous hydrolysis of the glycosidic bond that connect