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Cover Picture: Formal Desymmetrization of the Diastereotopic Chains in Gemini Calcitriol Derivatives with Two Different Side Chains at C-20 (Eur. J. Org. Chem. 8/2004)

✍ Scribed by Hubert Maehr; Milan R. Uskokovic

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 70 KB
Volume: 2004
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200490016

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✦ Synopsis

Abstract

The cover picture shows symbolizes light that sustains life and the continuous evolution intimately connected to the critical role of vitamin D and its biomolecular receptor. It demonstrates the ability of mankind to supplement this evolutionary process by their inventions that contribute to health and well‐being. Details are discussed in the article by H. Maehr and M. R. Uskokovic on p. 1703 ff.

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Formal Desymmetrization of the Diastereotopic Chains in Gemini Calcitriol Derivatives with Two Different Side Chains at C-20

✍ Hubert Maehr; Milan R. Uskokovic 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 204 KB 👁 1 views

## Abstract Derivatives of calcitriol with two equal side chains emanating at C‐20, also known as gemini, have emerged as interesting compounds, either as instruments for assessing the steric requirements of the vitamin D receptor or as drug candidates. We now describe the syntheses of gemini analo