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Cover Picture: Expression of PI(4,5)P2-binding proteins lowers the PI(4,5)P2 level and inhibits FcγRIIA-mediated cell spreading and phagocytosis – Eur. J. Immunol. 1/2008

✍ Scribed by Ewelina Szymańska; Andrzej Sobota; Edward Czuryło; Katarzyna Kwiatkowska

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
399 KB
Volume
38
Category
Article
ISSN
0014-2980

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Expression of PI(4,5)P2-binding proteins
Expression of PI(4,5)P2-binding proteins lowers the PI(4,5)P2 level and inhibits FcγRIIA-mediated cell spreading and phagocytosis
✍ Ewelina Szymańska; Andrzej Sobota; Edward Czuryło; Katarzyna Kwiatkowska 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB

## Abstract We found that FcγRII‐mediated cell spreading and phagocytosis were correlated with an increase of phosphatidylinositol 4,5‐bisphosphate [PI(4,5)P~2~] level in cells. During the spreading, a long‐lasting elevation of PI(4,5)P~2~ and concomitant actin polymerization occurred. Filopodia an