No coin nor oath required. For personal study only.
Issue no. 21 is a regular issue consisting of one FAST TRACK article on “Blinded study determination of high sensitivity and specificity microchip electrophoresis‐SSCP/HA to detect mutations in the p53 gene” and 19 other contributions distributed over 5 distinct parts. Part I is on proteins and proteomics containing 5 contributions describing on‐line combination of multiple chromatographic modes for multicomponent separation of proteomics and glycoproteomics, the heterogeneity of plasma‐derived clotting factor VIII, rapid species evaluation of seafood spoilage and pathogenic Gram‐positive bacteria by MALDI‐TOF mass fingerprinting, comparison of depletion and equalization strategies in proteomics, and a competent extraction method for 2‐D gel electrophoresis. Part II is on affinity capillary electrophoresis and has 2 contributions on the application of partial‐filling using lectins and glycosidases for the characterization of oligosaccharides in therapeutic antibodies, and on protonated diamines as anion‐binding agents and their utility in CE separations. 5 contributions on detection and sensitivity enhancement make up the body of Part III. DNA translocation and depurination constitute the content of the two contributions of Part IV. Finally, Part V assembles 5 papers on various fundamentals and methodologies including the influence of membrane layer properties on the electrophoretic behavior of a soft particle, evaluation of the separation mechanism of EKC with microemulsion and CDs using NMR and molecular modeling, linear polyalkylamines as fingerprinting agents in CE of low‐molecular weight heparins and glycosaminoglycans, use of CE‐SDS gel for the characterization of monoclonal antibody hinge region clipping due to copper and high pH stress, and electrophoretic isolation of saponin fractions from Saponinum album and their evaluation in synergistically enhancing the receptor‐specific cytotoxicity of targeted toxins. In short, this regular issue has a myriad of topics, which make the issue a must to read.
Featured articles include:
FAST TRACK: Blinded study determination of high sensitivity and specificity microchip electrophoresis‐SSCP/HA to detect mutations in the p53 gene ((10.1002/elps.201100396))
Online combination of reversed‐phase/reversed‐phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples ((10.1002/elps.201100092))
Trace determination of perchlorate using electromembrane extraction and capillary electrophoresis with capacitively coupled contactless conductivity detection ((10.1002/elps.201100279))
Sensitivity enhancement in capillary electrophoresis‐mass spectrometry of anionic metabolites using a triethylamine‐containing background electrolyte and sheath liquid ((10.1002/elps.201100271))
Evaluation of the separation mechanism of electrokinetic chromatography with a microemulsion and cyclodextrins using NMR and molecular modeling ((10.1002/elps.201100263))
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