Cover Picture: Direct Observation of Single Protein Molecules in Aqueous Solution (ChemPhysChem 4/2006)

✍ Scribed by David Grünwald; Andreas Hoekstra; Thomas Dange; Volker Buschmann; Ulrich Kubitscheck

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 35 KB
• Volume: 7
• Category: Article
• ISSN: 1439-4235
• DOI: 10.1002/cphc.200690011

✦ Synopsis

The cover picture shows a surface plot representation of the trajectories of a single quantum dot (larger signals in the back) and of a single fluorescent antibody (four smaller signals in the front) in aqueous buffer solution. In their Communication on page 812 Grünwald et al. show that imaging by an electron multiplying charge‐coupled device is fast enough to obtain images of diffusing single molecules. The antibody signals are not as bright as the quantum dots, and slighty more smeared out due to movements during the 3‐ms frame integration time.