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Cover Picture: Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties (ChemMedChem 1/2009)

✍ Scribed by Zachary K. Sweeney; Joshua J. Kennedy-Smith; Jeffrey Wu; Nidhi Arora; J. Roland Billedeau; James P. Davidson; Jennifer Fretland; Julie Q. Hang; Gabrielle M. Heilek; Seth F. Harris; Donald Hirschfeld; Petra Inbar; Hassan Javanbakht; Jesper A. Jernelius; Qingwu Jin; Yu Li; Weiling Liang; Ralf Roetz; Keshab Sarma; Mark Smith; Dimitrio Stefanidis; Guoping Su; Judy M. Suh; Armando G. Villaseñor; Michael Welch; Fang-Jie Zhang; Klaus Klumpp

Book ID: 102806181
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 879 KB
Volume: 4
Category: Article
ISSN: 1860-7179
DOI: 10.1002/cmdc.200990000

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Diphenyl Ether Non-Nucleoside Reverse Tr

Diphenyl Ether Non-Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

✍ Zachary K. Sweeney; Joshua J. Kennedy-Smith; Jeffrey Wu; Nidhi Arora; J. Roland 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 521 KB

## Abstract Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) are part of the preferred treatment regimens for individuals infected with HIV. These NNRTI‐based regimens are efficacious, but the most popular NNRTIs have a low genetic barrier to resistance and have been associated with adverse