Cover Picture: Construction of the Six- and Five-Membered Aza-Heterocyclic Units of the Isoindoloisoquinolone Nucleus by Parham-Type Cyclization Sequences − Total Synthesis of Nuevamine (Eur. J. Org. Chem. 16/2005)

Construction of the Six- and Five-Member

Construction of the Six- and Five-Membered Aza-Heterocyclic Units of the Isoindoloisoquinolone Nucleus by Parham-Type Cyclization Sequences –Total Synthesis of Nuevamine

✍ Anne Moreau; Axel Couture; Eric Deniau; Pierre Grandclaudon 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB

## Abstract An efficient methodology for the synthesis of isoindolo[1,2‐__a__]isoquinolones based on two Parham‐type cyclizations allowing the formation of the five‐ and six‐membered nitrogenated rings from carbamate or diacylamine precursors is described. The synthetic potential of this method has