✦ LIBER ✦

Cover Picture: Angew. Chem. Int. Ed. 6/2002

✍ Scribed by Warren G. Lewis; Luke G. Green; Flavio Grynszpan; Zoran Radić; Paul R. Carlier; Palmer Taylor; M. G. Finn; K. Barry Sharpless

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 68 KB
Volume: 41
Category: Article
ISSN: 0044-8249
DOI: 10.1002/1521-3773(20020315)41:6<875::aid-anie875>3.0.co;2-y

No coin nor oath required. For personal study only.

✦ Synopsis

The cover picture shows the electric eel, Electrophorus electricus, a source for commercially available acetylcholinesterase. In an experiment described by K. B. Sharpless and M. G. Finn and co-workers on pp. 1053 ± 1057, a femtomolar inhibitor was assembled by the enzyme from a collection of building blocks containing azide and alkyne functional groups, shown floating in solution. The templated 1,3-dipolar cycloaddition reaction, producing the inhibitor, is represented by the flare of light at the center of the image.

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