𝔖 Bobbio Scriptorium
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Covariance analysis of protein families: The case of the variable domains of antibodies

✍ Scribed by Laurence Choulier; Virginie Lafont; Nicolas Hugo; Danièle Altschuh

Book ID
101324685
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
262 KB
Volume
41
Category
Article
ISSN
0887-3585

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Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental