Covalently Linked at the Lower Rim Double‐Calix[4]arene as a Precursor for Multicavity Supramolecular Receptor

Proximal O,O′-capped calix[4]arenes with

Proximal O,O′-capped calix[4]arenes with a disiloxane bridge as highly efficient synthetic intermediates for 1,2-dialkylation at the lower rim

✍ Fumitaka Narumi; Naoya Morohashi; Nobuji Matsumura; Nobuhiko Iki; Hiroshi Kameya 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 88 KB

Treatment of calix[4] arenes with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane using imidazole as a base yielded O,O%bridged calixarenes in excellent yields, which were subsequently treated with an alkyl halide/base to give O¦,O §-dialkylated products in high yields. These were, in turn, amenable