Covalent surface modification of titanium oxide with different adhesive peptides: Surface characterization and osteoblast-like cell adhesion

✍ Scribed by Monica Dettin; Andrea Bagno; Roberta Gambaretto; Giovanna Iucci; Maria Teresa Conconi; Nunzio Tuccitto; Anna Michela Menti; Claudio Grandi; Carlo Di Bello; Antonino Licciardello; Giovanni Polzonetti

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 457 KB
• Volume: 90A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.32064

✦ Synopsis

Abstract

A fundamental goal in the field of implantology is the design of innovative devices suitable for promoting implant‐to‐tissue integration. This result can be achieved by means of surface modifications aimed at optimizing tissue regeneration. In the framework of oral and orthopedic implantology, surface modifications concern both the optimization of titanium/titanium alloy surface roughness and the attachment of biochemical factors able to guide cellular adhesion and/or growth. This article focuses on the covalent attachment of two different adhesive peptides to rough titanium disks. The capability of biomimetic surfaces to increase osteoblast adhesion and the specificity of their biological activity due to the presence of cell adhesion signal‐motif have also been investigated. In addition, surface analyses by profilometry, X‐ray photoelectron spectroscopy, and time of flight‐secondary ion mass spectrometry have been carried out to investigate the effects and modifications induced by grafting procedures. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009