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Covalent Protein−Oligonucleotide Conjugates for Efficient Delivery of Antisense Molecules

✍ Scribed by Rajur, S. B.; Roth, C. M.; Morgan, J. R.; Yarmush, M. L.


Book ID
125990955
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
173 KB
Volume
8
Category
Article
ISSN
1043-1802

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## Abstract Three methods for the conjugation of oligonucleotides to antibodies and the subsequent application of these conjugates to protein detection at attomole levels in immunoassays are described. The methods are based on chemical modification of both antibody and oligonucleotide. Aldehydes we