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Covalent modification of the interleukin-5 receptor by isothiazolones leads to inhibition of the binding of interleukin-5

✍ Scribed by René Devos; Yves Guisez; Geert Plaetinck; Sigrid Cornelis; Jan Tavernier; José Van Der Heyden; Louise H. Foley; Julie E. Scheffler


Book ID
115130528
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
624 KB
Volume
225
Category
Article
ISSN
1432-1327

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## Abstract Phage display was used to identify sequences that mimic structural determinants in interleukin5 (IL5) for IL5 receptor recognition. A coiled coil stem loop (CCSL) miniprotein scaffold library was constructed with its turn region randomized and panned for binding variants against human I