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Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators†

✍ Scribed by Kalgutkar, Amit S.; Kozak, Kevin R.; Crews, Brenda C.; Hochgesang, G. Phillip; Marnett, Lawrence J.

Book ID
111653989
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
613 KB
Volume
41
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Covalent Modificati
ChemInform Abstract: Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators.
✍ Amit S. Kalgutkar; Kevin R. Kozak; Brenda C. Crews; G. Phillip Jr. Hochgesang; L 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators. -Structure-activity relationship investigation of a series of title compounds, e.g. (I)-(IV), shows that, besides compounds (IIb), (IIf), (IIg), and (IVa), the recently