Covalent binding and glutathione depleti
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Ifeoma N. Oduah; Myrtle I. Thabrew; Godwin O. Emerole
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Article
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1985
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Springer-Verlag
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English
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In vivo and in vitro studies with rats have shown that (14C) niridazole (Ambilhar) binds covalently to tissue proteins, but not to nucleic acids. In the in vitro experiments, binding required the presence of NADPH in the incubation medium, suggesting the production of an active metabolite via a cyto