Covalent binding of 2,4,6-trinitrotoluene to human hemoglobin. Evidence for protein adducts probed by electrospray ionization mass spectrometry

Measurement of dissociation constants of

Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non-covalent electrospray ionization mass spectrometry

✍ S. W. Annie Bligh; Terry Haley; Peter N. Lowe 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 147 KB

## Abstract A mass spectrometric protocol for identifying ligands with a wide range of affinities (3–101 µM) and quantitative spectral analysis for non‐covalent interactions have been developed using Src SH2 as a target. Dissociation constants of five compounds, three with a phospho moiety, one wit

Covalent binding of 2,4,6-trinitrotoluene to human hemoglobin. Evidence for protein adducts probed by electrospray ionization mass spectrometry

✦ Synopsis