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Coupling of the antiviral agent zidovudine to polyaspartamide and in vitro drug release studies

✍ Scribed by G Giammona; G Cavallaro; G Fontana; G Pitarresi; B Carlisi


Book ID
114163558
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
206 KB
Volume
54
Category
Article
ISSN
0168-3659

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Coupling of the antiviral drug ara-AMP t
✍ Robert W. Jansen; Johan K. Kruijt; THEO J. C. van Berkel; Dirk K. F. Meije πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 767 KB

We covalently coupled 9-P-D-arabinofuranosyladenine 5'-monophosphate (ara-AMP) to the carrier molecule Iactosaminated human serum albumin using a water-soluble carbodiimide with a two-step conjugation method (pH 4.5 and pH 7.5) instead of the commonly used single-step conjugation at pH 7.5. This res