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Coupling of function, metabolism, and blood flow in the brain

โœ Scribed by Wolfgang Kuschinsky

Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
509 KB
Volume
14
Category
Article
ISSN
0344-5607

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โœฆ Synopsis

Functional activity, metabolism and blood flow are locally heterogeneous in the brain, but tightly coupled. This adjustment occurs in two different ways: 1. Short-term, dynamic coupling mediated by local vasoactive factors that ensure second-to-second regulation. 2. Long-term, static coupling apparently mediated by capillary density and developed in response to local functional and metabolic activity. Recognizing these two mechanisms permits one to distinguish apparent from real uncoupling. It allows the conclusion that there is no indication of an uncoupling of metabolism and blood flow during physiological conditions.

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## Abstract The relationships between brain electrical and metabolic activity are being uncovered currently in animal models using invasive methods; however, in the human brain this relationship remains not well understood. In particular, the relationship between noninvasive measurements of electri