Coupled column liquid chromatography for the trace determination of polar pesticides in water using direct large-volume injection: method development strategy applied to methyl isothiocyanate
✍ Scribed by E.A. Hogendoorn; C. Verschraagen; U.A.Th. Brinkman; P. van Zoonen
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 930 KB
- Volume
- 268
- Category
- Article
- ISSN
- 0003-2670
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✦ Synopsis
The potential of coupled column liquid chromatography (LC) for the trace determmatlon of a single polar compound by direct large-volume mJectlon of aqueous samples was studred and a general approach to method development for this class of compound IS discussed As a new apphcatlon, the determmatlon of methyl lsothlocyanate (MITC) by means of reversed-phase (RP) LC column mtchmg and UV detection at 237 nm IS reported With direct mjecfion of 770-4 samples, the detectlon hnut IS 1 pg 1-l and the time of analysis IS about 10 mm For a further increase m SekCtM@ and detectabdlty (down to a level of about 0 1 pg l-l), a rapid hqmd-hqmd extraction followed by an orgamc-aqueous phase switch on a slhca cartridge IS required poor to RPLC No residues of MITC were found m over 200 surface water samples investigated Keywords hquld chromatography, Methyl lsothmcyanate, Pesticides, Waters
Reversed-phase column liquid chromatography (RPLC) can be used to determme small amounts of polar organic compounds m (enwonmental) water samples An important advantage of RPLC m conJunctlon with aqueous samples IS