A series of 45 high-risk breast cancer patients, consisting of 25 affected individuals from 16 families in China with at least two cases of breast cancer and 20 cases of breast cancer diagnosed under age 35 without reported family history, were studied for germline mutations of the BRCA1 and BRCA2 g
β¦ LIBER β¦
Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility
β Scribed by Johnson, N.; Fletcher, O.; Palles, C.; Rudd, M.; Webb, E.; Sellick, G.; dos Santos Silva, I.; McCormack, V.; Gibson, L.; Fraser, A.; Leonard, A.; Gilham, C.; Tavtigian, S. V.; Ashworth, A.; Houlston, R.; Peto, J.
- Book ID
- 121840218
- Publisher
- Oxford University Press
- Year
- 2007
- Tongue
- English
- Weight
- 163 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0964-6906
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## Abstract There is conflicting evidence as to whether individuals who are heterozygous for germβline __BRCA1__ or __BRCA2__ mutations have an altered phenotypic cellular response to irradiation. To investigate this, chromosome breakage and apoptotic response were measured after irradiation in per