Counterion effects on transfection activity of cationic lipid emulsion
β Scribed by Young Jin Kim; Tae Woo Kim; Hesson Chung; Ik Chan Kwon; Seo Young Jeong
- Publisher
- The Korean Society for Biotechnology and Bioengineering
- Year
- 2001
- Tongue
- English
- Weight
- 286 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1226-8372
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract In an effort to enhance the geneβtransfer efficiencies of cationic lipids and to decrease their toxicities, a series of new phosphoramidate lipids with chemical similarity to cell membrane phospholipids was synthesised. These lipids contained various cationic headgroups, such as arginin
Emulsion formulations of various particle sizes for the highly lipophilic antitumour agent, RS-1541 (1 3-O-palmitoylrhizoxin), were prepared using dioctanoyldecanoylglycerol (ODO) as lipids and polyoxyethylene-(60)-hydrogenated castor oil (HCO-60) as a surfactant. These emulsions were evaluated as i