✦ LIBER ✦

Coumarin-based prodrugs 2. Synthesis and bioreversibility studies of an esterase-sensitive cyclic prodrug of dadle, an opioid peptide

✍ Scribed by Binghe Wang; Wei Wang; Huijuan Zhang; Daxian Shan; Terrill D. Smith

Book ID: 104364672
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 245 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00526-4

No coin nor oath required. For personal study only.

✦ Synopsis

A coumarin-based esterase-sensitive cyclic prodrug of an opioid peptide, DADLE, was prepared. The cyclic prodrug quickly released (tl/2 = 761 min) its original peptide, DADLE, upon esterase catalyzed hydrolysis. Such a system can be used for the preparation of cyclic prodrugs of other biologically active peptides aimed at improving their bioavailability.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Coumar

ChemInform Abstract: Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymic Stability

✍ Binghe Wang; Daxian Shan; Wei Wang; Huijuan Zhang; Olafur Gudmundsson; Ronald T. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

A Modified Coumarinic Acid-Based Cyclic

A Modified Coumarinic Acid-Based Cyclic Prodrug of an Opioid Peptide: Its Enzymatic and Chemical Stability and Cell Permeation Characteristics

✍ Hui Ouyang; Fuxing Tang; Teruna J. Siahaan; Ronald T. Borchardt 📂 Article 📅 2002 🏛 Springer US 🌐 English ⚖ 136 KB

Characterization of the Efflux Transport

Characterization of the Efflux Transporter(s) Responsible for Restricting Intestinal Mucosa Permeation of an Acyloxyalkoxy-Based Cyclic Prodrug of the Opioid Peptide DADLE

✍ Fuxing Tang; Ronald T. Borchardt 📂 Article 📅 2002 🏛 Springer US 🌐 English ⚖ 112 KB

ChemInform Abstract: Synthesis and Evalu

ChemInform Abstract: Synthesis and Evaluation of Novel Coumarin-Based Esterase-Sensitive Cyclic Prodrugs of Peptidomimetic RGD Analogues with Improved Membrane Permeability.

✍ Binghe Wang; Wei Wang; Gian P. Camenisch; Jennifer Elmo; Huijuan Zhang; Ronald T 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

ChemInform Abstract: Synthesis of an Est

ChemInform Abstract: Synthesis of an Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymatic Stability Using an Acyloxyalkoxy Promoiety

✍ Sanjeev Gangwar; Giovanni M. Pauletti; Teruna J. Siahaan; Valentino J. Stella; R 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 2 views

ChemInform Abstract: Synthesis of an Est

ChemInform Abstract: Synthesis of an Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymic Stability Using a 3-(2′-Hydroxy-4′,6′-dimethylphenyl)-3,3-Dimethylpropionic Acid Promoiety

✍ Binghe Wang; Sanjeev Gangwar; Giovanni Pauletti; Teruna Siahaan; Ronald T. Borch 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views