Could a high cholesterol diet cause Alzheimer's disease in Western Society? [Hypothesis]

✍ Scribed by Robyn J. Holden

• Book ID: 101281362
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 76 KB
• Volume: 14
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199904)14:3<185::aid-hup84>3.0.co;2-p

✦ Synopsis

Epidemiological studies have found dierent prevalence rates for Alzheimer's disease in African-Asian, Saudi Arabian and European-American Societies. It is hypothesized that high cholesterol diet may account for the dierence in these prevalence rates given that elevated cholesterol can induce extracellular acidi®cation which, in turn, increase the expression of tumor necrosis factor-alpha. In this paper, a neuroimmunological explanation is advanced that outlines a possible causal pathway that leads from extracelular acidi®cation and elevated tumor necrosis factor-alpha to the three leading chacterisitics of Alzhemier's disease: senile plaques, neuro®brillary tangles and cognitive de®cits.