Cough Threshold for Capsaicin Increases by Azelastine in Patients with Cough-variant Asthma

✍ Scribed by T. Shioya; N. Ito; M. Sasaki; M. Kagaya; M. Sano; T. Shindo; M. Kashima; M. Miura

• Book ID: 102619441
• Publisher: Elsevier
• Year: 1996
• Tongue: English
• Weight: 77 KB
• Volume: 9
• Category: Article
• ISSN: 0952-0600
• DOI: 10.1006/pulp.1996.0007

✦ Synopsis

To assess the effects of azelastine in patients with cough-variant asthma, we measured the cough threshold for capsaicin (the concentration required to elicit more than five coughs) in 16 patients with coughvariant asthma before and after 4 weeks of treatment with azelastine (2 mg; b.i.d.) or placebo. After treatment, coughing decreased in all patients and the cough threshold for capsaicin increased significantly, from 0.67±0.30  to 4.76±1.55  (P<0.01) in the azelastine group. However, the cough threshold for capsaicin did not increase significantly, from 0.86±0.33  to 1.11±0.35  (P>0.10) in the placebo group. These results suggest that azelastine inhibits coughing in patients with cough-variant asthma.