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Cotinine determination by immunoassays may be influenced by other nicotine metabolites

✍ Scribed by Georg Schepers; Rüdiger-Alexander Walk

Book ID: 104708644
Publisher: Springer-Verlag
Year: 1988
Tongue: English
Weight: 277 KB
Volume: 62
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00293630

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✦ Synopsis

Polyclonal rabbit anticotinine antiserum, which can be used for biomonitoring nicotine uptake by the determination of cotinine in body fluids, was checked by a competitive ELISA for its cross-reactivity with nine nicotine metabolites. The highest percentage of relative cross-reactivity (about 30%) was observed with trans-3'-hydroxycotinine, a metabolite which is known to be excreted in 3-fold higher amounts than cotinine in the urine of human smokers. Therefore, it is possible that cotinine determinations performed by immunochemical methods--especially in urine--may yield overestimated cotinine concentrations.

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