Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells

Epidermal growth factor (EGF) promotes c

Epidermal growth factor (EGF) promotes chemomigration of a human prostate tumor cell line, and EGF immunoreactive proteins are present at sites of metastasis in the stroma of lymph nodes and medullary bone

✍ Rajan, Rishi; Vanderslice, Rick; Kapur, Shakti; Lynch, John; Thompson, Rik; Djak 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 798 KB

Prostate tumor cells preferentially metastasize to bony sites and lymph nodes at a frequency in excess of that which would be predicted by random tumor cell dissemination. In order to determine whether chemoattractants in these organs promote organ-specific metastasis, we utilized human cell lines d