This investigation provides evidence that a 60-Hz electromagnetic field (EMF) at 1 gauss (G) can drive differentiation of cultured hematopoietic progenitor cells. HL-60 cells are known to differentiate from a nonphagocytic suspension culture to an attached fibroblast-like culture with high phagocyti
Costunolide induces differentiation of human leukemia HL-60 cells
β Scribed by Jung-Hye Choi; Bo-Rim Seo; Seong-Hoon Seo; Kyung-Tae Lee; Jae-Hoon Park; Hee-Juhn Park; Jong-Won Choi; Yoshie Itoh; Ken-ichi Miyamoto
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 704 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0253-6269
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## Abstract Various compounds active in promoting in vitro differentiation of certain murine leukemia cell lines (Friend erythroleukemia cells and mouse myeloid leukemia cells) were tested for their capacity to induce differentiation of HLβ60 cells, a human promyelocytic leukemia cell line capable
When cultured in Mg restricted medium, human leukemic HL-60 cells develop morphological and functional granulocytic differentiation. In 0.03 mM Mg, cells display the distinctive features of differentiation, without appreciable inhibition of proliferation. In 0.01 mM Mg, cells show terminal different
The role of magnesium ions in the differentiation of human promyelocytic leukemia HL-60 cells was investigated. When HL-60 extracellular magnesium was deficient (less than 0.01 mM), the total intracellular magnesium content and [3H] leucine incorporation rates decreased to 61 and 28%, respectively,