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Costimulatory Effect of IL-12 on the Activation of Naive, Memory CD4+T Cells, and Th1 Clone

✍ Scribed by Takuma Kato; Tatsuaki Morokata; Osamu Igarashi; Sung-Tae Yee; Manabu Inobe; Toshimitsu Uede; Miyuki Azuma; Ko Okumura; Hideo Nariuchi


Book ID
112239738
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
181 KB
Volume
176
Category
Article
ISSN
0008-8749

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The role of TGF-g 1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-g 1 has a profound inhibitory effect on naive CD4 + T cell undergoing