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Costimulation Requirement for AP-1 and NF-κB Transcription Factor Activation in T Cells

✍ Scribed by STEFFEN JUNG; AVRAHAM YARON; IRIT ALKALAY; ADA HATZUBAI; AYELET AVRAHAM; YINON BEN-NERIAH


Book ID
119871890
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
396 KB
Volume
766
Category
Article
ISSN
0890-6564

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CTLA4 is currently viewed as a late-appearing T cell surface receptor which is able to inhibit the proliferation of activated T cells. We sought to identify how CTLA4 ligation exerts these anti-proliferative effects by studying its influence on the activities of the relevant nuclear transcription fa