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Costello syndrome and hyperinsulinemic hypoglycemia

✍ Scribed by Saji Alexander; Dina Ramadan; Haya Alkhayyat; Ibrahim Al-Sharkawi; K.C. Aboo Backer; Fatma El-Sabban; Khalid Hussain

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
137 KB
Volume
139A
Category
Article
ISSN
1552-4825

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We describe a 34-year-old woman with mental retardation, short stature, macrocephaly, a ''coarse'' face, hoarse voice, and redundant skin with deep palmar and plantar creases who had evident Costello syndrome. Lacking papillomata, she had wartlike lesions of the skin. The previously reported patient

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## Abstract Costello syndrome is a rare but increasingly recognized syndrome of unknown etiology. Neurological abnormalities are not rare in this syndrome and consist of structural and electrophysiological disorders. Ventricular dilatation is observed in more than 40% of cases. Other reported cereb