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Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats

โœ Scribed by S. C. Heinrichs; Alwin Klaassen; George F. Koob; Gery Schulteis; Serge Ahmed; Errol B. De Souza


Publisher
Springer
Year
1998
Tongue
English
Weight
438 KB
Volume
136
Category
Article
ISSN
0033-3158

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Cocaine, as does exposure to other physiological stressors, releases brain corticotropin releasing factor (CRF), and this release habituates during the course of repeated cocaine administration in animals. Due to the many signs of anxiety and responses to stress that are produced by cocaine withdraw