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Corticotropin-releasing factor family and its receptors: pro-inflammatory or anti-inflammatory targets in the periphery?

✍ Scribed by Huayuan Zhu; Juejin Wang; Jianyong Li; Shengnan Li

Book ID: 105753468
Publisher: SP Birkhäuser Verlag Basel
Year: 2011
Tongue: English
Weight: 212 KB
Volume: 60
Category: Article
ISSN: 1420-908X
DOI: 10.1007/s00011-011-0329-2

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## Abstract Corticotropin‐releasing factor (CRF), the principal regulator of the hypothalamus‐pituitary‐adrenal (HPA) axis, also modulates the inflammatory response directly, via its effect on mast cells and macrophages. On macrophages, it augments production of lipopolysaccharide (LPS)‐induced pro