Corticotropin-releasing factor binding sites in cortex of depressed suicides
β Scribed by D. Hucks; Sandra Lowther; M. Rufus Crompton; Cornelius L. E. Katona; R. W. Horton
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 188 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
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Cocaine, as does exposure to other physiological stressors, releases brain corticotropin releasing factor (CRF), and this release habituates during the course of repeated cocaine administration in animals. Due to the many signs of anxiety and responses to stress that are produced by cocaine withdraw
## Abstract Corticotropin releasing factor (CRF) and its cognate receptors, defined as Type 1 and Type 2 have been localized within the cerebellum. The Type 2 CRF receptor (CRFβR2) is known to have both a full length (CRFβR2Ξ±) and a truncated (CRFβR2Ξ±βtr) isoform. A recent study documented CRFβR2Ξ±