Corticosteroid-induced abnormality in fetal mice andH-2haplotype: Evidence of a cytoplasmic effect
✍ Scribed by Michael Melnick; Mary Marazita; Tina Jaskoll
- Publisher
- Springer-Verlag
- Year
- 1983
- Tongue
- English
- Weight
- 352 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0093-7711
No coin nor oath required. For personal study only.
✦ Synopsis
Different strains of H-2 congenic mice have different susceptibilities to corticosteroid-induced fetal loss and cleft palate. Applying this knowledge, we tested the null hypothesis, which assumes that there are no statistically significant differences in the frequency of abnormality among various types of treated backcross offspring and, thus, no evidence of a cytoplasmic effect. In the present study this null hypothesis was frequently, but not consistently, rejected. Therefore, there was some evidence of a cytoplasmic effect. One possible explanation of these results is seen When one considers the phenotypic effects of "gene-gene interaction" between variant H-2 genotypes and an invariant mitochondrial genotype.