Corticosteroid action on choroid plexus: Reduction in Na+—K+-ATPase activity, choline transport capacity, and rate of CSF formation

✍ Scribed by M. Lindvall-Axelsson; P. Hedner; C. Owman

• Book ID: 104681495
• Publisher: Springer-Verlag
• Year: 1989
• Tongue: English
• Weight: 620 KB
• Volume: 77
• Category: Article
• ISSN: 0014-4819
• DOI: 10.1007/bf00249613

✦ Synopsis

Glucocorticoids have a well-known clinical effect on brain edema and intracranial hypertension, but the mechanism of action is still poorly understood. In the present report the effect of beta-methasone on choroid plexus transport and CSF formation was studied. Following 5 days of daily treatment with betamethasone the CSF production rate in rabbits was reduced by 43% as measured by ventriculo-cisternal perfusion with radioactive inulin. Accordingly, the transport capacity in the choroid plexus, measured in terms of choline uptake and accumulation in vitro, and the activity of Na+--K+-ATPase decreased in both rabbit (in the lateral ventricles by 31 and 31%, respectively) and rat (by 16 and 24%, respectively). Thus, the demonstrated influence of glucocorticoids on these functions of the choroid plexus seem to be important components in their therapeutic effect on intracranial hypertension.