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Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control

✍ Scribed by Bee Leng Lua; Boon Chuan Low


Book ID
116465247
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
294 KB
Volume
579
Category
Article
ISSN
0014-5793

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An important feature of cytochrome P450 (CYP) 2B1 is its high ability to convert the prodrug cyclophosphamide (CPA) to therapeutically cytotoxic metabolites, resulting in interstrand DNA-cross-linking and cell death. We have examined whether and how the phosphorylation of CYP2B1 influences CPA metab