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Corrigendum to “Mechanistic considerations pertaining to the solvolysis of paclitaxel analogs bearing ester groups at the C2′ position”: [Tetrahedron Lett. 42 (2001) 7747]

✍ Scribed by Wieslaw A. Klis; Jeffrey G. Sarver; Paul W. Erhardt

Book ID: 104253045
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 38 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00106-0

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✦ Synopsis

The HPLC conditions associated with the retention times for the paclitaxel-related compounds listed in Table 1 should read as follows: RT=Retention times on an analytical HPLC (Waters) equipped with a reversed-phase column (Suplecosil C18) using gradient elution (60% acetonitrile in water going to 75% acetonitrile over a 10 min time period and maintained at 75% acetonitrile through the remainder of the elution) at a flow rate of 1.2 ml/min monitored by UV detection (225 nm).

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Mechanistic considerations pertaining to

Mechanistic considerations pertaining to the solvolysis of paclitaxel analogs bearing ester groups at the C2′ position

✍ Wieslaw A Klis; Jeffrey G Sarver; Paul W Erhardt 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 76 KB

Dilute solutions of paclitaxel-related derivatives having chloroacetyl esters in the C2% position undergo ready methanolysis according to pseudo first-order kinetics while more concentrated solutions appear to be stabilized, possibly by the formation of hydrophobic aggregates that tend to bury this