Enantioselective route to ferrugine and
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Michal Sienkiewicz; Urszula Wilkaniec; Ryszard Lazny
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Article
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2009
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Elsevier Science
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French
⚖ 264 KB
A simple enantioselective approach to ferrugine (2a-benzoyltropane) and its methyl analogue (2-acetyltropane) is reported. The four-step sequence uses an enantioselective aldol reaction of tropinone with benzaldehyde or acetaldehyde, combined with an aldol deoxygenation via tosylhydrazone reduction