𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Correspondence. Circulating Immune Complexes in Primary Sclerosing Cholangitis

✍ Scribed by Anastasios A. Mihas; John E. Volanakis; Ralph E. Schrohenloher; Tony A. Mihas; Henry C. Bodenheimer Jr.; Nicholas F. Larusso; Walter R. Thayer Jr.; Colette Charland; Parker J. Staples; Jurgen Ludwig; M. Roggendorf; F. Deinhardt; Gert G. FrÖSner

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
399 KB
Volume
4
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

We read with interest the report by Dr. Bodenheimer et al. (1) of elevated circulating immune complexes (CICs) in primary sclerosing cholangitis (PSC). Although not stated in the paper, we are the first to suggest that CICs may play a role in the pathogenesis of PSC. We recently described elevated CICs in patients with PSC associated with ulcerative colitis (CUC) (2). Although Bodenheimer's results confirm our findings, there are some differences in methodology. As shown in Table 1, our results with the C1,-binding assay method are in TABLE 1. ELEVATED CIC IN P s c (%) Bodenheimer Mihas et al. et al. Method ~ ~ RC-RA" 70 CI,,-BA~ 58 0 60

may account for the results. Failure of our assay system seems unlikely because it has produced reliable data in other diseases (3, 4). Despite these differences, we support the view that immunologic mechanisms may be operative in the pathogenesis of PSC.

Raji cell radioimmunoassay. C1,-binding assay.

almost perfect agreement with those obtained by Bodenheimer et al.

(1) (60 vs. 58%). However, we did not have similar results with the Raji cell radioimmunoassay method since, in our study, AO patient with'PSC had detectable CICs. The reasons for this discrepancy are not clear, although differences in patient populations

📜 SIMILAR VOLUMES

Elevated Circulating Immune Complexes in
Elevated Circulating Immune Complexes in Primary Sclerosing Cholangitis
✍ Henry C. Bodenheimer Jr.; Nicholas F. Larusso; Walter R. Thayer Jr.; Colette Cha 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 664 KB

Primary sclerosing cholangitis (PSC) is a syndrome of unknown etiology characterized by an association with inflammatory bowel disease in 50% or more cases. Since altered immunity, including circulating immune complexes, has been implicated in the pathogenesis of inflammatory bowel disease, we postu

Cancer surveillance in patients with pri
Cancer surveillance in patients with primary sclerosing cholangitis
✍ Nataliya Razumilava; Gregory J. Gores; Keith D. Lindor 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 274 KB 👁 2 views

Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory syndrome involving the biliary tract, often accompanied by inflammatory bowel disease (IBD). This syndrome is a prototype disease linking chronic inflammation to carcinogenesis. Indeed, PSC is associated with an increased risk of ch

HLA DPB polymorphism in primary sclerosi
HLA DPB polymorphism in primary sclerosing cholangitis and primary biliary cirrhosis
✍ James A. Underhill; Peter T. Donaldson; Derek G. Doherty; Koji Manabe; Roger Wil 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 515 KB

In recent years there has been an increasing interest in the link between susceptibility to autoimmune liver disease and genes of the HLA system, although the role of the DPBl locus in British patients has only been investigated in autoimmune hepatitis. The aim of the current study was to determine

Diagnostic and therapeutic challenges in
Diagnostic and therapeutic challenges in pediatric primary sclerosing cholangitis
✍ Benjamin L. Shneider 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 813 KB

is, therefore, an important indication for pediatric liver transplantation. This review summarizes current challenges in the diagnosis and treatment of this rare form of pediatric liver disease.