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Correolide and Derivatives Are Novel Immunosuppressants Blocking the Lymphocyte Kv1.3 Potassium Channels

✍ Scribed by Gloria C. Koo; Joseph T. Blake; Kashmira Shah; Mary Jo Staruch; Francis Dumont; Denise Wunderler; Manuel Sanchez; Owen B. McManus; Anna Sirotina-Meisher; Paul Fischer; Robert C. Boltz; Michael A. Goetz; Robert Baker; Jianming Bao; Frank Kayser; Kathleen M. Rupprecht; William H. Parsons; Xin-Chun Tong; Ida E. Ita; Jim Pivnichny; Stella Vincent; Paul Cunningham; Don Hora Jr.; William Feeney; Gregory Kaczorowski; Martin S. Springer


Book ID
112240192
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
128 KB
Volume
197
Category
Article
ISSN
0008-8749

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The lymphocyte potassium channels Kv1.3
✍ Jenny Lam; Heike Wulff πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 213 KB

## Abstract The voltage‐gated Kv1.3 and the calcium‐activated KCa3.1 potassium channel modulate many calcium‐dependent cellular processes in immune cells, including T‐cell activation and proliferation and have therefore been proposed as novel therapeutic targets for immunomodulation. Kv1.3 is highl