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Correlations of CTLA-4 gene polymorphisms and hepatitis C chronic infection

✍ Scribed by Debora L. S. Danilovic; Maria C. Mendes-Correa; Érika U. Lima; Heverton Zambrini; Raffaelle K. Barros; Suemi Marui

Book ID
115293882
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
139 KB
Volume
32
Category
Article
ISSN
0106-9543

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Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1\*0301 and DRB1\*0401. The gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4) on chromosome 2q33 may also influence autoimmuni